Albert Kligman’s Agent Orange Experiments
By James Donahue
When he died in 2010 Dr. Albert Kligman was lauded in obituary accounts as a dermatologist who co-invented
the acne medication, Retin-A. But the former prisoners at Philadelphia’s Holmesburg Prison and their families remember
him as the evil scientist who injected them with dioxin, the main ingredient in Agent Orange, to study the effect the chemical
had on their bodies, and many other chemicals.
The prisoners selected for the dioxin experiment were mostly black men, all of them objects of the
experiment funded by Dow Chemical, Johnson & Johnson and the U. S. Army. The experiments were conducted between 1965 and
The prisoners were injected with massive doses of dioxin, and the results were horrible. The subjects
suffered from severe acne, blackheads, cysts, pustules and other outbreaks on the face, armpits and groin. They continued
to suffer from the effects of the chemical for years later.
The military used Agent Orange as a jungle defoliant against the North Vietnamese army during the
Vietnam War. The stuff was sprayed down upon the soldiers, the towns and the civilians from aircraft from 1961, long before
Kligman’s experiments began, and continued to 1971, long after the effects of dioxin were known.
Kligman’s experiments with the prisoners continued from 1951 to 1974. He paid the prisoners
to let him use their bodies to test toothpaste, deodorants, shampoo, skin creams, detergents, liquid diets, eye drops, foot
powders and hair dye. Other tests involved mind-altering drugs, radioactive isotopes, and exposure to pathogens like herpes,
staphylococcus and athlete’s foot.
The Kligman experiments were brought to an end in 1974 after Allen Hornblum joined the prison staff,
was shocked at what he observed going on, and wrote a book, "Acres of Skin: Human Experiments at Holmesburg Prison; A True
Story of Abuse and Exploitation in the Name of Medical Science."
Holmesburg’s book stirred a wave of national attention. There were congressional hearings. And
the Kligman experiments came to an abrupt end.
In a personal interview, Holmesburg said: "It was chilling to be in a totalitarian atmosphere, which
a prison is, and to see minorities – the prison was about 85 percent black and there were very few high school graduates
– to see all of these people involved in some medical experiment about which they had a minimal amount of information."
Kligman held a Ph.D in botany from the University of Pennsylvania and an M.D. from the University’s
medical school. He specialized in fungi and dermatology.
He was called to Holmesburg Prison in 1951 because an estimated 1,200 prisoners were plagued by an
outbreak of athlete’s foot. He later told a newspaper reporter about the day he first arrived at the prison: "All I
saw before me were acres of skin. It was like a farmer seeing a field for the first time."
About 300 people, subjects of the Kligman tests, later filed suit against Kligman, the University
of Pennsylvania and Johnson & Johnson. The experiments have since become a textbook example of unethical experimenting.
What went on at Holmesburg Prison has been compared to the "barbarity and sadism of Auschwitz and Dachau."